Serotonin release as a possible mechanism of reserpine action.
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منابع مشابه
Ability of serotonin and norepinephrine to mimic the central effects of reserpine on vasomotor activity.
EM P L O Y I N G electroneurographic technics, Bein and McCubbin and Page have shown that a significant portion of the acute cardiovascular effects of reserpine is mediated centrally. The mechanism involved is not known but, since serotonin has been shown to inhibit central synaptic transmission, Brodie et al. and Shore et al. have suggested that the sedative effect of reserpine might depend up...
متن کاملDrug interactions with vesicular amine transport.
A large body of evidence has implicated monoamine neurotransmitters in a range of behavioral phenomena including mood. Reserpine depletes monoamines and induces a syndrome resembling depression (Frize 1954), giving rise to the monoamine hypothesis of affective disorders. In addition, many drugs used to treat depression act by inhibiting the reuptake of norepinephrine and serotonin from the syna...
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Protection against anaphylactic shock in mice by reserpine has been shown to be a delayed phenomenon, probably not dependent upon a direct effect of reserpine. The release and depletion of catechol amines by reserpine show little likelihood of being responsible for protection because these substances are in themselves protective against anaphylactic shock, while beta-TM 10, a drug which interfe...
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Recent studies in this laboratory of platelets from patients with rheumatoid arthritis and nonrheumatoid inflammatory states (1) have emphasized the importance of the transport system or systems concerned with absorption and release of serotonin by platelets. There is no agreement or definite knowledge concerning such transport mechanisms at present. Born, Ingram and Stacey (2) reported a posit...
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Evidence that tranquilising action of reserpine is associated with change in brain serotonin and not in brain epinephrine by B.B. A reserpine analogue, dimethylaminobenzoyl methyl reserpate (SU5171) can release half the brain nor-epinephrine in rabbits without releasing significant amounts of brain serotonin and without eliciting sedation. Larger doses release both amines and induce marked seda...
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عنوان ژورنال:
- Science
دوره 122 3165 شماره
صفحات -
تاریخ انتشار 1955